Metatarsalgia is the term used to describe pain or discomfort in the sole of the foot, where the bones from the middle of the foot (metatarsals) articulate with the toes. A detailed examination leading to a clear diagnosis is needed, as many conditions can cause pain in this area. For example, a fatigue or stress fracture, which can develop with intermittent excess loading on a specific bone, often a metatarsal, causes pain and is sometimes accompanied by swelling.